Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology |
| Bernard Testa; Joachim Mayer |
| Many drugs and other xenobiotics (e.g., preservatives, insecticides and plastifiers) contain hydrolysable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolotic reactions catalyzed by hydrolases or preceeding non-encymatically. Despite their significance, unti now no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs anf other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and hydarion from the point of views of enzymes, substrates and reactions.
|
|
| Cloth Bound |
400 Pages
|
Item #:
Price: |
390639025X
$230.00 |
John Wiley & Sons, Inc. | |
