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Mass Spectrometry in Biophysics: Conformation and Dynamics of Biomolecules |
| Wiley - Interscience Series on Mass Spectrometry |
| Igor A. Kaltashov (University of Massachusetts); Stephen J. Eyles (Director of Mass Spectrometry and Molecular Weight Characterization Facility at the University of Massachusetts) |
| The first systematic summary of biophysical mass spectrometry techniques Recent advances in mass spectrometry (MS) have pushed the frontiers of analytical chemistry into the biophysical laboratory. As a result, the biophysical community's acceptance of MS-based methods, used to study protein higher-order structure and dynamics, has accelerated the expansion of biophysical MS.
Despite this growing trend, until now no single text has presented the full array of MS-based experimental techniques and strategies for biophysics. Mass Spectrometry in Biophysics expertly closes this gap in the literature. Covering the theoretical background and technical aspects of each method, this much-needed reference offers an unparalleled overview of the current state of biophysical MS. Mass Spectrometry in Biophysics begins with a helpful discussion of general biophysical concepts and MS-related techniques. Subsequent chapters address: *Modern spectrometric hardware *High-order structure and dynamics as probed by various MS-based methods *Techniques used to study structure and behavior of non-native protein states that become populated under denaturing conditions *Kinetic aspects of protein folding and enzyme catalysis *MS-based methods used to extract quantitative information on protein-ligand interactions *Relation of MS-based techniques to other experimental tools *Biomolecular properties in the gas phase Fully referenced and containing a helpful appendix on the physics of electrospray mass spectrometry, Mass Spectrometry in Biophysics also offers a compelling look at the current challenges facing biomolecular MS and the potential applications that will likely shape its future.
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| Cloth Bound |
458 Pages, 6-1/8 x 9-1/4 in.
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0471456020
$99.95 |
John Wiley & Sons, Inc. | |
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