Mouse Models of Cancer |
| Editor: Eric C. Holland |
| This groundbreaking text systematically presents the principles, methodology, applications, and challenges of mouse models of human cancer. Divided into five sections, the primary focus of this book is the generation of genetically accurate models of specific human cancer types. The introduction covers nonspecific modeling systems, with chapters on animal handling, comparison of mouse and human developmental genetics and cancer, and pathology techniques. The following section covers methods for genetic manipulation of the mouse. The core section on diseases is organized by organ system, in which a brief overview of the biology of each of the main human tumor types and the current mouse modeling systems that mimic those tumors is discussed. The next section focuses on anatomic and molecular imaging techniques from CT and MRI to bioluminescence, fluorescence, and PET. The last section covers topics related to preclinical trials, from trial design to pharmacokinetics and finally regulatory issues. A final chapter provides a perspective on future directions for the field.
|
|
| Cloth Bound |
Pages, 8-1/2 x 11 in.
|
Item #:
Price: |
047144460X
$230.00 |
John Wiley & Sons, Inc. | |
