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Combinatorial Chemistry: From Theory to Application, 2nd, Revised Edition |
| Editor: Willi Bannwarth (University of Freiburg, Germany); Editor: Berthold Hinzen (Bayer AG, Wuppertal, Germany); Series Editor: Raimund Mannhold (University of Düsseldorf, Germany); Series Editor: Hugo Kubinyi (University of Heidelberg, Germany); Series Editor: Gerd Folkers (ETH Zürich, Switzerland) |
| This revolutionary method enables organic and medicinal chemists to synthesize thousands or even millions of potentially interesting compounds in a single reaction sequence. Combined with current methods of high throughput analysis, combinatorial methods have almost completely replaced the traditional step-by-step synthesis of potential drugs. Retaining its practice-oriented approach, this new edition has been thoroughly updated to reflect recent developments in parallel synthesis, while a new chapter on screening complements the overview of combinatorial strategy and synthetic methods. The result is a handbook tailored to the needs of the industry, with almost all the authors affiliated with leading pharmaceutical companies.
From the contents: *Purification Principles in High-Speed Solution Phase Synthesis *Linkers for Solid-Phase Organic Synthesis (SPOS) and Combinatorial Approaches on Solid Support *Cyclative Cleavage - A Versatile Concept in Solid-Phase Organic Chemistry *C-C Bond Forming Reactions *Combinatorial Synthesis of Heterocycles *Polymer-Supported Reagents: Preparation and Use in Parallel Organic Synthesis *Encoding Strategies for Combinatorial Libraries *Automation and Devices for Combinatorial Chemistry and Parallel Organic Synthesis *Assays for High Throughput Screening in Drug Discovery *Computer-Assisted Library Design *Appendix: Cheminformatics and Web Resources for Combinatorial Chemistry For organic and medicinal chemists, chemists in industry, and the pharmaceutical industry.
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| Cloth Bound |
694 Pages
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Item #:
Price: |
3527306935
$230.00 |
John Wiley & Sons, Inc. | |
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