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Vector Targeting for Therapeutic Gene Delivery |
| Editor: David T. Curiel; Editor: Joanne T. Douglas |
| The ability to deliver therapeutic genes effectively is the most important requirement for the success of gene therapy interventions. Representing the discipline’s first authoritative text, Vector Targeting for Therapeutic Gene Delivery clearly presents the most recent advances in target definition technology and the principles underlying the rational design of targeted vectors for gene therapy. The book’s first section focuses on transductional targeting strategies designed to achieve the selective delivery of the therapeutic gene by both nonviral and viral vectors; the second section discusses transcriptional targeting, in which the therapeutic gene is placed under the control of transcriptional regulatory sequences that are activated in the disease cells, but not in normal cells, and therefore target expression selectively to the tumor cell. Other sections consider the variety of strategies that can be employed to define appropriate cellular targeting moieties and strategies to monitor the extent of gene expression.
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| Cloth Bound |
Pages, 6-1/8 x 9-1/4 in.
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Item #:
Price: |
0471434795
$185.00 |
John Wiley & Sons, Inc. | |
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